Current Status and Future of our R&D

Current Status and Future of our Research & Development

We, ORTHOREBIRTH, have obtained our own technology and know-hows so far through our development of Cottony Bone-Regenerative Materials (Its commercial name in USA is ReBOSSIS.) Now, we have been actively making diversifying types of R&Ds by applying such technology and know-hows to medical innovations. Some of such R&Ds have just started, and others have been progressing so well that we have been expecting a good success in the future. Among our various R&Ds, we would like to introduce to you the following two R&Ds.

■Development of Antibacterial Synthetic Bone Void Filler with The Consistency of Cotton:

Here in Japan where the population of aged people has been increasing rapidly, many of such aged patients have been suffering from any bone/joint-diseases. This is leading to the increase in the cases of bone/joint operations among them. Simultaneously, it has become more and more important to prevent bacteria/virus infection in patients’ bones and joints.

Then, ORTHOREBIRTH has started the following project by tying up with Meiji University, Nagoya Institute of Technology and Keio University. The project aims to realize “Development of Antibacterial Synthetic Bone Void Filler with The Consistency of Cotton”featured with a proper antibacterial capability, especially after an operation, and with easiness of handling.

Back in September of 2016, this project became the target of subsidy by NEDO (New Energy and Industrial Technology Development Organization), and since then, this project has been progressing very well.

A plan of the detailed development under this project is as follows:1) We are planning to ask Meiji University (Dr. Mamoru Aizawa) to give us a good support in combining silver, famous for its antibacterial property, with our ReBOSSIS and one of its materials, β-TCP, and do In-Vitro Evaluation. 2) We are also planning to ask Nagoya Institute of Technology (Dr. Toshihiro Kasuga) help us obtain the most optimal conditions for cottony-material molding process in our joint development. 3) We are also planning to ask Keio University (Dr. Mamoru Matsumoto and Dr. Takashi Ishii) to do In-Vivo Evaluation by use of rabbits in which the prototype of this product is embedded.

Like above-explained, this project is to develop artificial bone filling materials with antibacterial property and make a practice use of such innovative materials. For this purpose, we are going to combine silver, renowned for its antibacterial property, and our cottony ReBOSSIS with good absorbing capability, which will lead to the prevention of post-operation infections. If we successfully realize the use of such innovative ReBOSSIS, it will be highly expected to reduce a lot of risk for post-operation infection for the sake of patients who have bone/joint operations. Thus, we think we will surely be able to contribute to the improvement of their QOL.


■ Application of Cottony Materials as Drug Carrier

One of the remarkable features of ReBOSSIS is cottony as it looks.ReBOSSIS is a lump of very fine fibers of micrometers. The technical features of ReBOSSIS are as follows:

[1] To make biological water-absorbent polymer into fibers and form a lump of cotton.

[2] To leave any foreign materials in our body thanks to biological absorption.

[3] Medical properties are easy to be mixed into the cottony lump and such medical ingredients are designed to be released gradually.

Based on these three properties, we have been thinking of utilizing our ReBOSSIS as Drug Carrier. In this application, ReBOSSIS does not contain any ingredients for bone regeneration. The main body of the cottony-shape was created in the process of our development of ReBOSSIS.

The study on the use of ReBOSSIS as Drug Carrier has been studies by Dr. Shin’ya Ikematsu at National Institute of Technology, Okinawa College and our ORTHOREBIRTH Okinawa Laboratory. The researchers have developed a cottony item combined with anti-cancer agent, and have repeated their experiments in which they implant such cottony item combined with anti-cancer agent in mice. So far, the researchers have been having a sure feeling of success through the experiments.

In our method, anti-cancer agent contained in a cottony item is designed to be set at affected areas of a cancer patient and be released for a long period. This method is very kind to our body. General types of anti-cancers, oral-intake or IV-drip, move around our whole body, causing strong side-effects. On the other hand, our developed cottony item combined with anti-cancer agent is set at the affected areas of a patient’s body. The Ingredients of the anti-cancer agent are designed to work effectively for a long time, expectedly reducing the risk of side-effect.