TODAY AND TOMORROW
OF OUR RESEARCH & DEVELOPMENT

Cell Culture Substrates

In collaboration with the University of the Ryukyus in Okinawa, we have been conducting R&D on substrates for extracting and culturing adipose-derived stem cells. By utilizing these substrates, the process of isolating and culturing stem cells from fatty tissue becomes remarkably efficient.
The extraction and culture sheet—composed of microfibers—also functions as a bioabsorbable scaffold for 3D tissue regeneration, which sets it apart. This product has already been commercialized under the name "Stem Cell Extraction and Culture Sheet [For Research Use]" and has been available since December 2018. Currently, we are advancing research aimed at even greater efficiency in cell cultivation, with plans to release a new generation of culture substrates.

Combined Use of BMP and Cotton-Like Artificial Bone

For treating bone defects and non-unions caused by tumors or trauma, autologous bone grafting—where bone is harvested from a patient’s iliac crest—is a common method. However, this technique is not without challenges, including limited bone availability, pain at the donor site, and potential complications such as fractures.

To address these issues, our research focuses on the use of Bone Morphogenetic Proteins (BMPs), which play an essential role in physiological bone formation, including skeletal development and fracture healing. In the U.S., two types of BMPs—BMP-2 and BMP-7/OP-1—have been approved by the Approved by the U.S. Food and Drug Administration (FDA). Of these, BMP-2 has seen wide clinical use in orthopedic treatments, a trend also observed in Europe.

That said, BMPs are not without drawbacks. Their strong bone-inducing capabilities, coupled with the inability to remain localized, can lead to a phenomenon known as "ectopic ossification"—where bone forms in unintended areas.
To mitigate such risks, we are exploring a method that combines BMP with our proprietary cotton-like artificial bone. This composite material, containing β-TCP, the key mineral component involved in bone formation, supports safe and efficient bone regeneration. With this BMP-enhanced formulation, we aim to expand treatment capabilities for larger bone defects than previously possible.

Antibacterial Cotton-Shaped Artificial Bone

As Japan’s population continues to age, the number of orthopedic surgeries involving bones and joints is expected to increase significantly. At the same time, preventing postoperative infections caused by bacteria at surgical sites is becoming increasingly critical.
To address this challenge, ORTHOREBIRTH has initiated a development program focused on creating an “antibacterial cotton-shaped artificial bone” that combines infection prevention with superior handling characteristics.
In fiscal year 2016, this project was selected for a three-year commissioned research initiative by NEDO (New Energy and Industrial Technology Development Organization), and it has already yielded promising results.
Research and development are currently underway, and upon successful practical implementation, this technology is expected to significantly reduce the incidence of postoperative infections.